MEASURING, PREDICTING, AND ENGINEERING PROTEIN INTERACTIONS
at Scale

A-Alpha Bio harnesses synthetic biology and machine learning to precisely engineer high-impact medicines.

By measuring millions of protein-protein interactions simultaneously, we accelerate innovation and improve human health.

Billionprotein-protein interactions measured to date

Antibody – Antigen
Interactions
Antibody – Antigen
Interactions
E3 Ligase – Neo-Degron
Interactions
E3 Ligase – Neo-Degron
Interactions
Other Protein – Protein
Interactions
Other Protein – Protein
Interactions
Our approach

Fueling Discoveries with High-Throughput Data and Machine Learning

Protein-protein interactions govern all of biology and are crucial for understanding and combating disease.

However, a lack of abundant and high-quality protein-protein interaction data limits our understanding and ability to treat cancers, infectious diseases, neurological diseases, and more.

A-Alpha Bio generates the high-throughput data needed to discover rare and effective antibodies, identify degradable neo-substrates, engineer protein interfaces, and fuel predictive machine learning models to further accelerate the discovery and optimization of high-impact drugs.

Continuous improvement graph
OUR TECHNOLOGY

AlphaSeq + AlphaBind

Platform cycle

Measuring and Predicting Protein-Protein Interactions at an Unprecedented Scale

AlphaSeq is the leading platform for quantitative and multiplexed characterization of protein-protein interactions. Leveraging synthetic biology, we have generated the largest repository of high-quality protein interaction data in the world.

AlphaBind harnesses our accumulated data to train machine learning models capable of predicting binding from protein sequence. Computational designs are measured experimentally for model validation and refinement through rapid iterations.

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Platform cycle
    OUR PARTNERS

    We partner with leading companies and institutions who share our mission to improve human health.

    Learn more about our AlphaSeq + AlphaBind Platforms.